N-GLYCOLYLNEURAMINIC ACID-CONTAINING GLYCOCONJUGATE AS TUMOR-ASSOCIATED ANTIGEN
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چکیده
منابع مشابه
Characterization of /V-Glycolylneuraminic Acid-containing Gangliosides as Tumor-associated Hanganutziu-Deicher Antigen in Human Colon Cancer1
Hanganutziu-Deicher (HD) antigen-active A/-glycolylneuraminic acid (NeuGc)-containing gangliosides were isolated and charac terized from human colon cancer tissues. The antigenic ganglio sides were detected by thin-layer chromatography by our newly developed method (H. Higashi, Y. Fukui, S. Ueda, S. Kalo, Y. Hirabayashi, M. Matsumoto, and M. Naiki. J. Biochem., 95: 1517-1520, 1984) of enzyme im...
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The breast cancer-associated epitope (mammary serum antigen or MSA) defined by monoclonal antibody (Mab) 3E1.2 is a neuraminidase-sensitive carbohydrate expressed on MUC-1-encoded molecules. However, the reactivity of Mab 3E1.2 is also reduced by protease treatment of the mucin, which suggests that 3E1.2 binds to multimers of the sialylated carbohydrate in a protein conformation-dependent manne...
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The rotavirus spike protein domain VP8* is essential for recognition of cell surface carbohydrate receptors, notably those incorporating N-acylneuraminic acids (members of the sialic acid family). N-Acetylneuraminic acids occur naturally in both animals and humans, whereas N-glycolylneuraminic acids are acquired only through dietary uptake in normal human tissues. The preference of animal rotav...
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Classic studies suggested that the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) is an oncofetal antigen in humans, being immunogenic in adult humans and yet apparently expressed in human fetuses and tumors. We and others have recently found that the human deficiency of Neu5Gc can be explained by an inactivating mutation in the gene encoding CMP-N-acetylneuraminic acid hydroxy...
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N-Glycolylneuraminic acid (Neu5Gc) is a non-human sialic acid, which may play a significant role in human pathologies, such as cancer and vascular disease. Further studies into the role of Neu5Gc in human disease are hindered by limited sources of this carbohydrate. Using a chemo-enzymatic approach, Neu5Gc was accessed in six steps from glucose. The synthesis allows access to gram-scale quantit...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1990
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.2.7